Palabras clave
Enfermedad periodontal – Síndrome de Down
Cómo citar
La enfermedad periodontal asociada al paciente con Síndrome de Down. (2011). Odontoestomatología, 13(18), 4-15. https://www.odon.edu.uy/ojs/index.php/ode/article/view/157
Resumen
El Síndrome de Down es una de las condiciones de discapacidad más comunes. Dentro de las patologías bucales más prevalentes, la enfermedad periodontal es una de las asociadas con este síndrome. Se considera que la persona con Síndrome de Down presenta una mayor susceptibilidad a contraer esta enfermedad. En este artículo se describen los factores etiológicos y las características clínicas de la enfermedad en pacientes portadores del síndrome.
Referencias
Epstein CJ, Koremberg JR et al. Protocols to establish genotype-phenotype correlations in Down Syndrome. Am J Hum Genet 1991; 49:207-35
Brown R. H.; Cunninghan N W. M.: Some Dental Manifesta tions of Mongolism. Oral Surg., Oral Med. & Oral Pathol, 1961; 14; 664-665.
Kroll R.G.; Budnick J.; Kobren A.: Inciden-ce of Dental Caries and Periodontal Disease in Down`s Syndrome. N.J. State D.J. ; 1970 36:151-53.
Keyes DM. Study on the pathogenesis of destructive lesions with Down syndrome. J Clin Pediat. 1971: 10:711-718.
Zardo Coelho, C. R.; Loevy H. T.: Aspectos Odontológicos da Síndrome de Down. Ars Cvrandi em Odontologia: 1982 9:16-18.
Ulseth J. O.; Hestnes A.; Stovner L. J.; et al.: Dental Caries and Periodontitis in Persons with Down syndrome. Special Care in Dentistry, 1991; 11 (2): 71-73.
Amano A.; Kishima T.; Akiyama S.; et al.: Relationship of periodontopathic bacteria with early-onset periodontitis in Down’s syndrome. J Periodontol 2001 72(3):368-73.
Sasaki y.; Sumi Y.; Miyasaki Y.; et al.: Periodontal management of an adolescent with Down’s syndrome – a case report. Int J Paediatric Dent. 2004 14(2):127-35.
Cohen M, Winer RA et al Periodontal disease in a group of mentally subnormal children. J Dental Res 1960; 39:745.
Hannelore T.: Periodon tal Disease in Patients with Down`s Syndrome. Miniclinic CDS Review 1979; 23- 23.
Reuland Bosma W et al Periodontal disease in Down syndrome; a review. J Clin Periodontol 1986; 13: 64-73.
Barnett ML et al. The prevalence of periodontitis and dental caries in a Down syndrome population. J Periodontol 1986; 57:288-93
Modéer T, Barr M et al. Periodontal disease in children with Down syndrome. Scand J Dent Res 1990; 98:228-34.
Yohihara T, et al. Effect of periodic preventive care on the progression of periodontal disease in young adults with Down´s syndrome. J Clin Periodontol 2005; 32:556-60.
Archila LE, Descripción de la enfermedad periodontal en pacientes con Síndrome de Down de cuatro institutos de Santa Fe de Bogotá. Rev Odontol de la Universidad Del Bosque 1992:1-17.
Cichon P, Crawford L, Grimm WD.: Earlyonset periodontitis associated with Down’s syndrome—clinical interventional study. Ann Periodontol 1998; 3(1):370-80
Armitage G.C.: Desarrollo de un sistema de clasificación para enfermedades y condiciones periodontales. Ann. Periodontal 1999; 4: 1-6.
Williams R.C.; Offenbacher S.: Periodontal medicine: the emergence of a new branch of periodontology. Periodontol 2000. 2000 Jun; 23:9-12.
Asokan S, Muthu MS et al. OraL Finding Of Down Syndrome children in Chennai, India. Indian J Dent Res 2008; 19, 230-5.
Johnson H.; Young A.: Periodontal Disease in Mongols. Periodontal 1963: 34; 41-47
Amano A, Marakami J. et al Etiologic factors of early onset periodontal disease in Down Syndrome. Japanese Dent Science Rew. 2008 44, 118-127
Lopez Perez R y col. Oral hygiene, gingivitis and periodontitis in persons with Down syndrome. Spec Care dentist 2002 Nov-Dec 22(6) 214-20.
Sakellari D, et al. Periodontal conditions and subgingival microflora in Down syndrome patients. A case control study. J Clin Periodontol 2005 Jun32 (6): 684-90.
Weinstein R.; Carrassi A.; Donelli C.et al.: Condi zioni Paradontali in Pazienti aff etti da Trisomia 21: Rassegna Bibliografi ca. Mondo Odontostomatologico; 1984; 5:13-18.
Ahmed Khocht, DDS et al . Periodontal health in Down syndrome: Contributions of mental dishability, personal, and professional dental care.Spec Care Dentist 2010 30(3): 118-123.
Saxén L.; Aula S.; Westermack T.:Pe riodontal Disease Associated with Down`s Syndrome: An Orthopantomo graphic Evaluation. J. Periodontol. 1997; 48 (6), 337-340.
Saxén L.; Aula A S.: Periodontal Bone Loss in Patients with Down’s Syndrome: A follow up Study. J. Periodontal. 1982; 3:.53-56.1
Weinstein R.; Strohmenger L.; Donelli C.: Patologia Dento Parodontale in un Gruppo do Soggetti Adulti Affetti da Sindrome di down. Mondo Odontostomatologico. 1984; 5: 23-25.
Agholme MB, Dahllof G, Modeer T.: Chan-ges of periodontal status in patients with Down syndrome during a 7-year period. Eur J Oral Sci 1999 107(2):82-8.
Barr-Agholme M, Dahllof G, Modeer T, et al.: Periodontal conditions and salivary immunoglobulin’s in individuals with Down syndrome. J Periodontol 1998; 69(10):1119-23
Diaz Rosas L, Lopez Morales PM. Revisión de los aspectos inmunológicos de la enfermedad periodontal en pacientes pediátricos con Síndrome de Down. Rev. ADM 2006 vol. LXIII Nº 4 Jul/Ag 125-31.
Zaldivar-Chiapa RM, Arce Mendoza AY et al. Evaluation of surgical and non-surgical periodontal therapies, and immunological status, of young Downs’s syndrome patients. J Periodontol 2005; 76:1061-32.
Yavuzilmaz E.; Ersoy F.; Sanal O.; et al.: Neutrophil Chemotaxis and Periodontal Status in Down’s syndrome patients. J. Nihon Univ Sch Dent. 1993; 35: 91-95.
Kumar S, Sharma J et al. Determinants for oral hygiene and periodontal status among mentally disabled children and adolescents. J. of Indian Society of Pedodontics and Prev. Dentistry. 2009:27(3) 151-157.
Lopez P et al. Gingivitis en una comunidad infantil mexicana con trisomía 21. División de estudios de Postgrado e investigación. F.O. UNAM 2000, 11:5-13
Ruiz M.; Moreu G.; Romero M.: Destrucción Periodontal en el Síndrome de Down y en la Periodontitis Juvenil. Rev. Europea de Odonto-estomatología 1994; 6(5): 13-16.
Vigild M.: Periodontal Conditions in Mentally Retarded Children. Conmunity Dent Oral Epidemiol 1985; 13: 180-182.
Orner G. Periodontal Disease among children with Downs Syndrome and their siblings. J Dental Res 1976 September-October :55(5):778-782.
Takanobu Morinushi, Denis Lopatin et al. A comparison of the gingival health of children with Down syndrome to Healthy children residing in an institution. Spec Care Dentist 2006 26(1), 13-19.
Cogulu D Sabah E et al. Genotyping of streptococcus mutans by using arbitrarily primed polymerase chain reaction in children whith Down syndrome. Archives of oral Biology 2006. 51. 177-82.
Santangelo CN, Gomez DP.Avaliacao das características bucais de pacientes portadores de Síndrome de Down da APAE de Mogi das Cruces-SP. 2008 ConScientiae Saude :7 (1) 29-34.
Bandeira T, Pereira V y col. Síndrome de Down, Aspectos gerais e odontológicos. 2004. Ci. Med Biol., Salvador v3 nº2 252-260.
Morales Chavez M, Naukart Z. Prevalencia de maloclusiones en pacientes con Síndrome de Down. Oral revista. 2009 ; 10 ( 32) 537-539.
Desai SS. Down syndrome. A review of the literature. Oral Surge Oral Med Oral Pathol Oral Radiol endod. 1997 184: 297-85.
Waldman HB, Hasan FM, Perlman S.Down Syndrome and sleep-Disordered breathing. J Am Dent Assoc , 2009 vol 140 N 3 , 307;312.
Sato K, Shirakawa T, et al .Effects of oral care in Down syndrome children with obstructive sleep apnea. J of Oral Cience, 2010 :52 (1), 145-147.
Bagic I et al. Periodontal conditions in individuals with Down syndrome. Coll Antropol 2003: 27 suple 2 75-82.
Moraes, Mari Eli Leonelli de, Moraes , Luis Cesar de, et al. Dental anomalies in patients with Down syndrome. Braz. Dent J 2007:18(4):346-350.
López López J.; Rosello Llambres X.: Síndrome de Down y enfermedad periodontal; Estudio Clínico. Revista Europea de Odonto-Estomatología 1995; 7(2)11-13.
Lucarini G.; Biagini G.; et al, Lesioni Gengivali in corso di Paradon topatia in pazienti con Sindrome di Down. Dental Cadmos 1995; 12; 82-89.
Reuland -Bosma W, Van Der Reijden WA, Van Winkelhoff AJ.: Absence of a specifi c subgingival microflora in adults with Down’s syndrome. J Clin Periodontol 2001 28(11):1004-946.
Amano A Kishima T et al. Periodontopathic bacteria in children whit Down syndrome. J Periodontol 2000 28: 1004-9.
Hanookai D, et al . Herpes viruses and periodontopathic bacteria in trisonomy 21 periodontitis. J periodontol 2000; 71 : 376-84.
Barr-Agholme M, Modeer T, Luthman J.: Immunohistological study of neuronal markers in inflamed gingiva obtained from children with Down’s syndrome. J Clin Periodontol. 1991 18(8):624-33.
Lindhe J, Lang N et al. Periodontología Clínica e Implantología Odontológica .Ed. Panamericana 5ª Edición.
Izumi Y et al. Defective neutrophil chemotaxis in Down syndrome patients and its relationship to periodontal destruction. J Periodontol 1989:60:238-42.
Sreedevi H, Munshi AK.: Neutrophil chemotaxis in Down syndrome and normal children to Actinobacillus actinomycetemcomitans. J Clin Pediatr Dent 1998 22(2):141-6
Nicolo M.; Bucci P.: Paradon titi Associate a Malattie Sistemiche con Defi cit Qualitativo della Funzione Fagocita ria. Minerva Stomatologica 1989; 38 (8): 905-909.
Hodge D, Michalowicz B .Genetic predisposition to periodontitis in children and young adults. Periodontol 2000 2001;26 :113-114
Nancy J. Down síndrome and associated medical disorders. Research Reviews 1996;
2: 85-89.
Teng YT. Protective and destructive immunity in the periodontium : part 1- innate and humoral immunity and the periodontum. J Dent Res 2006; 85: 198-208.
Idivar-Chiapa RM et al. Evaluation and surgical and non-surgical periodontal therapies and immunological status of young Down syndrome patients. J Periodontol 2005 ; 76: 1061-5.
Barr AM, et al. Prostaglandin E2 level in gingival crevicular fluid from patients with Down syndrome. Acta Odontol Scand 1997; 55: 101-105.
Otsuka Y, Ito M, Yamaguchi M, Saito S, et al.; Enhancement of lipopolysaccharide-stimulated cyclooxygenase-2 mRNA expression and prostaglandin E2 production in gingival fibroblasts from individuals with Down syndrome. Mech Ageing Dev. 2002 31(6):663-74.
Tsilingardis G et al. Enhanced levels of prostaglandin E2, leukotriene B4, and matrix metalloproteinase-9 in gingival crevicular fl uid from patients with Down Syndrome Acta Odont Scand 1997: 55: 101-5.
Page RC. The role of infl ammatory mediators in the pathogenesis of periodontal disease. J Periodont Res 1991; 26: 230-42.
Iwamoto T, Yamada A et al. Infl uences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts.Archives of oral biology 2009: 54 963-969.
Duque A, Herrera AM et al. Polimorfi smo de IL1 como marcador genético de enfermedad periodontal. Revista CES Odontología 2007:20(1) 51 -58.
Khocht A, Heaney K et al. Association of interleukin-1 polymorphisms with periodontitis in Down syndrome. J of Oral Science 2011:53(2) 193-202.
Cavalcante LB, Pires JR, Scarel-Caminaga RM. Doenca Periodontal em individuos con syndrome de Down: Enfoque genetico. 2009 oct-dec. :57, (4) 449-453.
Brown R. H.; Cunninghan N W. M.: Some Dental Manifesta tions of Mongolism. Oral Surg., Oral Med. & Oral Pathol, 1961; 14; 664-665.
Kroll R.G.; Budnick J.; Kobren A.: Inciden-ce of Dental Caries and Periodontal Disease in Down`s Syndrome. N.J. State D.J. ; 1970 36:151-53.
Keyes DM. Study on the pathogenesis of destructive lesions with Down syndrome. J Clin Pediat. 1971: 10:711-718.
Zardo Coelho, C. R.; Loevy H. T.: Aspectos Odontológicos da Síndrome de Down. Ars Cvrandi em Odontologia: 1982 9:16-18.
Ulseth J. O.; Hestnes A.; Stovner L. J.; et al.: Dental Caries and Periodontitis in Persons with Down syndrome. Special Care in Dentistry, 1991; 11 (2): 71-73.
Amano A.; Kishima T.; Akiyama S.; et al.: Relationship of periodontopathic bacteria with early-onset periodontitis in Down’s syndrome. J Periodontol 2001 72(3):368-73.
Sasaki y.; Sumi Y.; Miyasaki Y.; et al.: Periodontal management of an adolescent with Down’s syndrome – a case report. Int J Paediatric Dent. 2004 14(2):127-35.
Cohen M, Winer RA et al Periodontal disease in a group of mentally subnormal children. J Dental Res 1960; 39:745.
Hannelore T.: Periodon tal Disease in Patients with Down`s Syndrome. Miniclinic CDS Review 1979; 23- 23.
Reuland Bosma W et al Periodontal disease in Down syndrome; a review. J Clin Periodontol 1986; 13: 64-73.
Barnett ML et al. The prevalence of periodontitis and dental caries in a Down syndrome population. J Periodontol 1986; 57:288-93
Modéer T, Barr M et al. Periodontal disease in children with Down syndrome. Scand J Dent Res 1990; 98:228-34.
Yohihara T, et al. Effect of periodic preventive care on the progression of periodontal disease in young adults with Down´s syndrome. J Clin Periodontol 2005; 32:556-60.
Archila LE, Descripción de la enfermedad periodontal en pacientes con Síndrome de Down de cuatro institutos de Santa Fe de Bogotá. Rev Odontol de la Universidad Del Bosque 1992:1-17.
Cichon P, Crawford L, Grimm WD.: Earlyonset periodontitis associated with Down’s syndrome—clinical interventional study. Ann Periodontol 1998; 3(1):370-80
Armitage G.C.: Desarrollo de un sistema de clasificación para enfermedades y condiciones periodontales. Ann. Periodontal 1999; 4: 1-6.
Williams R.C.; Offenbacher S.: Periodontal medicine: the emergence of a new branch of periodontology. Periodontol 2000. 2000 Jun; 23:9-12.
Asokan S, Muthu MS et al. OraL Finding Of Down Syndrome children in Chennai, India. Indian J Dent Res 2008; 19, 230-5.
Johnson H.; Young A.: Periodontal Disease in Mongols. Periodontal 1963: 34; 41-47
Amano A, Marakami J. et al Etiologic factors of early onset periodontal disease in Down Syndrome. Japanese Dent Science Rew. 2008 44, 118-127
Lopez Perez R y col. Oral hygiene, gingivitis and periodontitis in persons with Down syndrome. Spec Care dentist 2002 Nov-Dec 22(6) 214-20.
Sakellari D, et al. Periodontal conditions and subgingival microflora in Down syndrome patients. A case control study. J Clin Periodontol 2005 Jun32 (6): 684-90.
Weinstein R.; Carrassi A.; Donelli C.et al.: Condi zioni Paradontali in Pazienti aff etti da Trisomia 21: Rassegna Bibliografi ca. Mondo Odontostomatologico; 1984; 5:13-18.
Ahmed Khocht, DDS et al . Periodontal health in Down syndrome: Contributions of mental dishability, personal, and professional dental care.Spec Care Dentist 2010 30(3): 118-123.
Saxén L.; Aula S.; Westermack T.:Pe riodontal Disease Associated with Down`s Syndrome: An Orthopantomo graphic Evaluation. J. Periodontol. 1997; 48 (6), 337-340.
Saxén L.; Aula A S.: Periodontal Bone Loss in Patients with Down’s Syndrome: A follow up Study. J. Periodontal. 1982; 3:.53-56.1
Weinstein R.; Strohmenger L.; Donelli C.: Patologia Dento Parodontale in un Gruppo do Soggetti Adulti Affetti da Sindrome di down. Mondo Odontostomatologico. 1984; 5: 23-25.
Agholme MB, Dahllof G, Modeer T.: Chan-ges of periodontal status in patients with Down syndrome during a 7-year period. Eur J Oral Sci 1999 107(2):82-8.
Barr-Agholme M, Dahllof G, Modeer T, et al.: Periodontal conditions and salivary immunoglobulin’s in individuals with Down syndrome. J Periodontol 1998; 69(10):1119-23
Diaz Rosas L, Lopez Morales PM. Revisión de los aspectos inmunológicos de la enfermedad periodontal en pacientes pediátricos con Síndrome de Down. Rev. ADM 2006 vol. LXIII Nº 4 Jul/Ag 125-31.
Zaldivar-Chiapa RM, Arce Mendoza AY et al. Evaluation of surgical and non-surgical periodontal therapies, and immunological status, of young Downs’s syndrome patients. J Periodontol 2005; 76:1061-32.
Yavuzilmaz E.; Ersoy F.; Sanal O.; et al.: Neutrophil Chemotaxis and Periodontal Status in Down’s syndrome patients. J. Nihon Univ Sch Dent. 1993; 35: 91-95.
Kumar S, Sharma J et al. Determinants for oral hygiene and periodontal status among mentally disabled children and adolescents. J. of Indian Society of Pedodontics and Prev. Dentistry. 2009:27(3) 151-157.
Lopez P et al. Gingivitis en una comunidad infantil mexicana con trisomía 21. División de estudios de Postgrado e investigación. F.O. UNAM 2000, 11:5-13
Ruiz M.; Moreu G.; Romero M.: Destrucción Periodontal en el Síndrome de Down y en la Periodontitis Juvenil. Rev. Europea de Odonto-estomatología 1994; 6(5): 13-16.
Vigild M.: Periodontal Conditions in Mentally Retarded Children. Conmunity Dent Oral Epidemiol 1985; 13: 180-182.
Orner G. Periodontal Disease among children with Downs Syndrome and their siblings. J Dental Res 1976 September-October :55(5):778-782.
Takanobu Morinushi, Denis Lopatin et al. A comparison of the gingival health of children with Down syndrome to Healthy children residing in an institution. Spec Care Dentist 2006 26(1), 13-19.
Cogulu D Sabah E et al. Genotyping of streptococcus mutans by using arbitrarily primed polymerase chain reaction in children whith Down syndrome. Archives of oral Biology 2006. 51. 177-82.
Santangelo CN, Gomez DP.Avaliacao das características bucais de pacientes portadores de Síndrome de Down da APAE de Mogi das Cruces-SP. 2008 ConScientiae Saude :7 (1) 29-34.
Bandeira T, Pereira V y col. Síndrome de Down, Aspectos gerais e odontológicos. 2004. Ci. Med Biol., Salvador v3 nº2 252-260.
Morales Chavez M, Naukart Z. Prevalencia de maloclusiones en pacientes con Síndrome de Down. Oral revista. 2009 ; 10 ( 32) 537-539.
Desai SS. Down syndrome. A review of the literature. Oral Surge Oral Med Oral Pathol Oral Radiol endod. 1997 184: 297-85.
Waldman HB, Hasan FM, Perlman S.Down Syndrome and sleep-Disordered breathing. J Am Dent Assoc , 2009 vol 140 N 3 , 307;312.
Sato K, Shirakawa T, et al .Effects of oral care in Down syndrome children with obstructive sleep apnea. J of Oral Cience, 2010 :52 (1), 145-147.
Bagic I et al. Periodontal conditions in individuals with Down syndrome. Coll Antropol 2003: 27 suple 2 75-82.
Moraes, Mari Eli Leonelli de, Moraes , Luis Cesar de, et al. Dental anomalies in patients with Down syndrome. Braz. Dent J 2007:18(4):346-350.
López López J.; Rosello Llambres X.: Síndrome de Down y enfermedad periodontal; Estudio Clínico. Revista Europea de Odonto-Estomatología 1995; 7(2)11-13.
Lucarini G.; Biagini G.; et al, Lesioni Gengivali in corso di Paradon topatia in pazienti con Sindrome di Down. Dental Cadmos 1995; 12; 82-89.
Reuland -Bosma W, Van Der Reijden WA, Van Winkelhoff AJ.: Absence of a specifi c subgingival microflora in adults with Down’s syndrome. J Clin Periodontol 2001 28(11):1004-946.
Amano A Kishima T et al. Periodontopathic bacteria in children whit Down syndrome. J Periodontol 2000 28: 1004-9.
Hanookai D, et al . Herpes viruses and periodontopathic bacteria in trisonomy 21 periodontitis. J periodontol 2000; 71 : 376-84.
Barr-Agholme M, Modeer T, Luthman J.: Immunohistological study of neuronal markers in inflamed gingiva obtained from children with Down’s syndrome. J Clin Periodontol. 1991 18(8):624-33.
Lindhe J, Lang N et al. Periodontología Clínica e Implantología Odontológica .Ed. Panamericana 5ª Edición.
Izumi Y et al. Defective neutrophil chemotaxis in Down syndrome patients and its relationship to periodontal destruction. J Periodontol 1989:60:238-42.
Sreedevi H, Munshi AK.: Neutrophil chemotaxis in Down syndrome and normal children to Actinobacillus actinomycetemcomitans. J Clin Pediatr Dent 1998 22(2):141-6
Nicolo M.; Bucci P.: Paradon titi Associate a Malattie Sistemiche con Defi cit Qualitativo della Funzione Fagocita ria. Minerva Stomatologica 1989; 38 (8): 905-909.
Hodge D, Michalowicz B .Genetic predisposition to periodontitis in children and young adults. Periodontol 2000 2001;26 :113-114
Nancy J. Down síndrome and associated medical disorders. Research Reviews 1996;
2: 85-89.
Teng YT. Protective and destructive immunity in the periodontium : part 1- innate and humoral immunity and the periodontum. J Dent Res 2006; 85: 198-208.
Idivar-Chiapa RM et al. Evaluation and surgical and non-surgical periodontal therapies and immunological status of young Down syndrome patients. J Periodontol 2005 ; 76: 1061-5.
Barr AM, et al. Prostaglandin E2 level in gingival crevicular fluid from patients with Down syndrome. Acta Odontol Scand 1997; 55: 101-105.
Otsuka Y, Ito M, Yamaguchi M, Saito S, et al.; Enhancement of lipopolysaccharide-stimulated cyclooxygenase-2 mRNA expression and prostaglandin E2 production in gingival fibroblasts from individuals with Down syndrome. Mech Ageing Dev. 2002 31(6):663-74.
Tsilingardis G et al. Enhanced levels of prostaglandin E2, leukotriene B4, and matrix metalloproteinase-9 in gingival crevicular fl uid from patients with Down Syndrome Acta Odont Scand 1997: 55: 101-5.
Page RC. The role of infl ammatory mediators in the pathogenesis of periodontal disease. J Periodont Res 1991; 26: 230-42.
Iwamoto T, Yamada A et al. Infl uences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts.Archives of oral biology 2009: 54 963-969.
Duque A, Herrera AM et al. Polimorfi smo de IL1 como marcador genético de enfermedad periodontal. Revista CES Odontología 2007:20(1) 51 -58.
Khocht A, Heaney K et al. Association of interleukin-1 polymorphisms with periodontitis in Down syndrome. J of Oral Science 2011:53(2) 193-202.
Cavalcante LB, Pires JR, Scarel-Caminaga RM. Doenca Periodontal em individuos con syndrome de Down: Enfoque genetico. 2009 oct-dec. :57, (4) 449-453.