Keywords
caveolae; tumor suppression, cell signaling, MMPs
How to Cite
CAVEOLINA-1 pathological and physiological implications. (2019). Odontoestomatología, 19(30), 91-97. https://www.odon.edu.uy/ojs/index.php/ode/article/view/167
Abstract
Caveolae are plasma membrane invaginations formed by proteins called caveolins. Of the three caveolin isoforms, the most studied one through years has been caveolin-1 (cav-1), which has an important role in cell signaling, and its gene, CAV-1, is part of the family of tumor suppressor genes. As its role depends
on the context, the participation and function of cav-1 in tumors is complex and remains controversial. Cav-1 interacts with a series of receptor molecules
that regulate the initial steps of cellular transformation to malignity. It also participates in the cell cycle, angiogenesis, extracellular matrix remodeling, cell proliferation, among other processes. The study of this molecule is important due to its function as a biomarker associated to the diagnosis, prognosis and therapeutic target in pathological processes.
References
1. Sherr, C.J. Principles of tumor suppression. Cell 2004; 116 (2): 235-46.
2. Yoshida, B.A.; Sokoloff, M.M.; Welch, D.R. & Rinker-Schaeffer, C.W. Metastasis-suppressor genes: a review and perspective on an emerging feld. J. Natl. Cancer Inst. 2000; 92 (21): 1717-30.
3. Cooper, G.M. Te Cell: A Molecular Approach. Tumor Suppressor Genes. 2nd edition. Sunderland (MA): Sinauer Associates 2000.
4. Hehlgans, S. & Cordes, N. Caveolin-1: an essential modulator of cancer cell radio and Chemoresistance. Am. J. Cancer. Res., 1 (4): 521-530, 2011.
5. Radu, V. Structure of caveolae. Biochym. et Biophy 2005; 1746, 334–348.
6. Boscher. C. & Nabi. I.R. Caveolin-1: role in cell signaling. Adv Exp Med Biol.2012; 729: 29-50.
7. Fridolfsson, H.N.; Roth, D.M.; Insel, P.A. & Patel, H.H. Regulation of intracellular signaling and function by caveolina. FASEB J. 2014; 28 (9): 3823–3831.
8. Fridolfsson, H.N.; Kawaraguchi, Y.; Ali, S.S.; Panneerselvam, M.; Niesman, I.R.; Finley, J.C.; et. al. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012; 26 (11): 4637-49.
9. Tagawa, A.; Mezzacasa, A.; Hayer, A.; Longatti, A.; Pelkmans, L. & Helenius, A.J. Assembly and trafcking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters. Cell Biol 2005; 29; 170 (5): 769-79.
10. Jeong, K.; Kwon, H.; Lee, J.; Jang, D.; Hwang, E.M.; Park, J.Y. & Pak, Y. Rab6-mediated retrograde transport regulates inner nuclear membrane targeting of caveolin-2 in response to insulin. Trafc.2012; 13 (9): 1218-33.
11. Bosch, M.; Marí, M.; Herms, A.; Fernández, A.; Fajardo, A.; Kassan, A, et al. Caveolin-1 defciency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr. Biol.2011; 26; 21 (8):681-6.
12. Razani, B.; Woodman, S.E. & Lisanti, M.P. Caveolae: from cell biology to animal physiology. Pharmacol. Rev 2002; 54: 431–67.
13. Lamaze, C. & Torrino, S. Caveolae and cancer: A new mechanical perspective. Biomed. J 2015; 38: 367-7.
14. Galbiati F.; Volonte D.; Liu J.; Capozza F.; Frank P.; Zhu L,; Pestell R. & Michael P. Lisanti.Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1 Arrest via a p53/p21WAF1/Cip1-dependent Mechanism. Biol. Cell.2001; 12 (8): 2229–2244.
15. Fang, K.; Fu, W.; Beardsley, A.R.; Sun, X.; Lisanti, M.P. & Liu, J. Overexpression of Caveolin-1 Inhibits Endothelial Cell Proliferation by Arresting the Cell Cycle at G0/G1 Phase. Cell Cycle2007; 6 (2): 199-204.
16. Goetz, J.G.; Lajoie, P. & Wiseman, S.M. Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer Metastasis Rev.2008; 27: 715-35.
17. Pancotti, F.; Roncuzzi, L. & Maggiolini, M. Caveolin-1 silencing arrests the proliferation of metastatic lung cancer cells through the inhibition of STAT3 signaling. Cell Signal. 2012;24: 1390-7.CAVEOLINA-1 implicaciones fsiológicas y patológicas 97
18. Bai, J.; Zhao, Y.; Dou, C. & Zhang, Z. Expression and role of Caveolin-1 in the angiogenesis of cerebral arteriovenous malformation. Zhonghua Yi Xue Za Zhi.2014; 94 (43): 3425-8.
19. Lacroix-Triki, M,; Geyer, F.C. & Reis-Filho, J.S. Caveolin-1 P132L mutation in human cancers: 1 CAV eat to be voiced. J Mol Diagn.2010; 12: 562-5.
20. Shan-Wei, W.; Kan-Lun, Xuc.; Shu-Qin, Ruana.; Li-Li, Zhaoa & Li-Rong, Chenc. Overexpression of Caveolin-1 in Cancer-Associated Fibroblasts Predicts Good Outcome in Breast Cancer. Breast Care 2012; 7: 477–483.
21. Bonuccelli, G.; Casimiro, M.C. & Sotgia, F. Caveolin-1 (P132L), a common breast cáncer mutation, confers mammary cell invasiveness and defnes a novel stem cell/metástasis-associated gene signature. Am J Pathol.2009; 174: 1650-62.
22. Haines, P.; Samuel, G.H.; Cohen, H.; Trojanowska, M. & Bujor, A.M. Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fbroblasts via inhibition of Erk1/2/Ets1 signaling pathway. J. Dermatol. Sci.2011; 64 (3): 210-6.
23. Kim, H.N. & Chung, H.S. Caveolin-1 inhibits membrane-type 1 matrix metalloproteinase activity. BMB Rep.2008; 31; 41 (12): 858-62.
24. Masuelli, L.; Budillon, A. & Mazocchella, L. Caveolin-1 overexpression is associated with simultaneous abnormal expression of the Ecadherin catenins complex and multiple ErbB receptors and with lymph nodes metástasis in head and neck squamous cell carcinomas. J. Cell. Physiol. 2011; 227: 3344-53.
2. Yoshida, B.A.; Sokoloff, M.M.; Welch, D.R. & Rinker-Schaeffer, C.W. Metastasis-suppressor genes: a review and perspective on an emerging feld. J. Natl. Cancer Inst. 2000; 92 (21): 1717-30.
3. Cooper, G.M. Te Cell: A Molecular Approach. Tumor Suppressor Genes. 2nd edition. Sunderland (MA): Sinauer Associates 2000.
4. Hehlgans, S. & Cordes, N. Caveolin-1: an essential modulator of cancer cell radio and Chemoresistance. Am. J. Cancer. Res., 1 (4): 521-530, 2011.
5. Radu, V. Structure of caveolae. Biochym. et Biophy 2005; 1746, 334–348.
6. Boscher. C. & Nabi. I.R. Caveolin-1: role in cell signaling. Adv Exp Med Biol.2012; 729: 29-50.
7. Fridolfsson, H.N.; Roth, D.M.; Insel, P.A. & Patel, H.H. Regulation of intracellular signaling and function by caveolina. FASEB J. 2014; 28 (9): 3823–3831.
8. Fridolfsson, H.N.; Kawaraguchi, Y.; Ali, S.S.; Panneerselvam, M.; Niesman, I.R.; Finley, J.C.; et. al. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012; 26 (11): 4637-49.
9. Tagawa, A.; Mezzacasa, A.; Hayer, A.; Longatti, A.; Pelkmans, L. & Helenius, A.J. Assembly and trafcking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters. Cell Biol 2005; 29; 170 (5): 769-79.
10. Jeong, K.; Kwon, H.; Lee, J.; Jang, D.; Hwang, E.M.; Park, J.Y. & Pak, Y. Rab6-mediated retrograde transport regulates inner nuclear membrane targeting of caveolin-2 in response to insulin. Trafc.2012; 13 (9): 1218-33.
11. Bosch, M.; Marí, M.; Herms, A.; Fernández, A.; Fajardo, A.; Kassan, A, et al. Caveolin-1 defciency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr. Biol.2011; 26; 21 (8):681-6.
12. Razani, B.; Woodman, S.E. & Lisanti, M.P. Caveolae: from cell biology to animal physiology. Pharmacol. Rev 2002; 54: 431–67.
13. Lamaze, C. & Torrino, S. Caveolae and cancer: A new mechanical perspective. Biomed. J 2015; 38: 367-7.
14. Galbiati F.; Volonte D.; Liu J.; Capozza F.; Frank P.; Zhu L,; Pestell R. & Michael P. Lisanti.Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1 Arrest via a p53/p21WAF1/Cip1-dependent Mechanism. Biol. Cell.2001; 12 (8): 2229–2244.
15. Fang, K.; Fu, W.; Beardsley, A.R.; Sun, X.; Lisanti, M.P. & Liu, J. Overexpression of Caveolin-1 Inhibits Endothelial Cell Proliferation by Arresting the Cell Cycle at G0/G1 Phase. Cell Cycle2007; 6 (2): 199-204.
16. Goetz, J.G.; Lajoie, P. & Wiseman, S.M. Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer Metastasis Rev.2008; 27: 715-35.
17. Pancotti, F.; Roncuzzi, L. & Maggiolini, M. Caveolin-1 silencing arrests the proliferation of metastatic lung cancer cells through the inhibition of STAT3 signaling. Cell Signal. 2012;24: 1390-7.CAVEOLINA-1 implicaciones fsiológicas y patológicas 97
18. Bai, J.; Zhao, Y.; Dou, C. & Zhang, Z. Expression and role of Caveolin-1 in the angiogenesis of cerebral arteriovenous malformation. Zhonghua Yi Xue Za Zhi.2014; 94 (43): 3425-8.
19. Lacroix-Triki, M,; Geyer, F.C. & Reis-Filho, J.S. Caveolin-1 P132L mutation in human cancers: 1 CAV eat to be voiced. J Mol Diagn.2010; 12: 562-5.
20. Shan-Wei, W.; Kan-Lun, Xuc.; Shu-Qin, Ruana.; Li-Li, Zhaoa & Li-Rong, Chenc. Overexpression of Caveolin-1 in Cancer-Associated Fibroblasts Predicts Good Outcome in Breast Cancer. Breast Care 2012; 7: 477–483.
21. Bonuccelli, G.; Casimiro, M.C. & Sotgia, F. Caveolin-1 (P132L), a common breast cáncer mutation, confers mammary cell invasiveness and defnes a novel stem cell/metástasis-associated gene signature. Am J Pathol.2009; 174: 1650-62.
22. Haines, P.; Samuel, G.H.; Cohen, H.; Trojanowska, M. & Bujor, A.M. Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fbroblasts via inhibition of Erk1/2/Ets1 signaling pathway. J. Dermatol. Sci.2011; 64 (3): 210-6.
23. Kim, H.N. & Chung, H.S. Caveolin-1 inhibits membrane-type 1 matrix metalloproteinase activity. BMB Rep.2008; 31; 41 (12): 858-62.
24. Masuelli, L.; Budillon, A. & Mazocchella, L. Caveolin-1 overexpression is associated with simultaneous abnormal expression of the Ecadherin catenins complex and multiple ErbB receptors and with lymph nodes metástasis in head and neck squamous cell carcinomas. J. Cell. Physiol. 2011; 227: 3344-53.