Complejo mcm2-7.

Revisión bibliográfica

  • Delmira Apellaniz Área de Patología Molecular Estomatológica, Facultad de Odontología, Universidad de la República, Uruguay http://orcid.org/0000-0003-3490-043X
  • Vanesa Pereira-Prado Área de Patología Molecular Estomatológica, Facultad de Odontología, Universidad de la República, Uruguay http://orcid.org/0000-0001-7747-6718
  • Gabriel Tapia-Repetto Cátedra de Histología, Facultad de Odontología, Universidad de la República, Uruguay http://orcid.org/0000-0003-4563-9142
  • Ronell Bologna-Molina Cátedra de Histología, Facultad de Odontología, Universidad de la República, Uruguay http://orcid.org/0000-0001-9755-4779
Palabras clave: complejo MCM2-7; proliferación celular; tumores

Resumen

La formación de nuevas células se genera a partir de células preexistentes a través de una serie ordenada de eventos denominada ciclo celular. El control de este es fundamental para la integridad del genoma, por lo que hay múltiples proteínas regulando este proceso. Actualmente, se conoce que el complejo MCM2-7 tiene un rol esencial en la replicación del ADN, específicamente involucrado en la proliferación, durante el ciclo celular. La identificación inmunohistoquimica de las proteínas de este complejo a nivel tisular, podría ser una herramienta muy útil, para usarlos como biomarcadores y así comprender uno de los mecanismos biológicos que se ven afectados en el cáncer.

Nuestro objetivo es realizar una revisión del complejo MCM2-7, ya que estas proteínas como se ha descrito, podrían comportarse como buenos marcadores biológicos de proliferación celular, y así poder realizar un buen diagnóstico, pronóstico y futuros blancos terapéuticos de aquellas lesiones principalmente neoplásicas , principalmente las que asientan a nivel de la mucosa bucal.

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Publicado
2019-02-20
Cómo citar
Apellaniz, D., Pereira-Prado, V., Tapia-Repetto, G., & Bologna-Molina, R. (2019). Complejo mcm2-7. Odontoestomatología, 20(32), 4-11. Recuperado a partir de https://www.odon.edu.uy/ojs/index.php/ode/article/view/38
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